Other symptoms may include headache, muscle aches, rash, and loss of appetite. The symptoms of infectious mononucleosis can vary, but often include fever, sore throat, swollen lymph nodes, fatigue, and enlarged spleen and liver. EBV infection can cause a condition called infectious mononucleosis, commonly referred to as 'mono' or the 'kissing disease.' Mono is a viral illness that is typically transmitted through close contact with infected saliva, such as through kissing, sharing utensils or drinking cups, or engaging in other activities that involve contact with infected saliva. Epstein-Barr virus (EBV) is a common virus that belongs to the herpesvirus family.